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專家人才

  • 姓名:彭廣敦
  • 性別:
  • 職稱:研究員
  • 學曆:
  • 電話:
  • 傳真:
  • 電子郵件:peng_guangdun@gibh.ac.cn
  • 通訊地址廣州市科學城開源大道190號

    簡曆:

  • 2009年博士畢業於中國科學院上海生物化學與細胞生物學研究所,美國加州大學洛杉磯分校(UCLA)博士後;回國後在中國科學院上海生物化學與細胞生物學先後擔任助理研究員、副研究員。20189月入職betway体育下载 ,擔任研究員、課題組長、博士生導師。為國家高層次青年人才,廣東省傑青,細胞譜係與發育研究中心副主任。

    研究領域:

  • “細胞學說”指出“所有生命體皆由細胞組成”,“細胞是生命的基本單元”以及“所有細胞都由此前的細胞變化而來”等核心概念,成為現代生物學的重要基石。然而,細胞的類型如何定義、細胞的過去現在和未來如何精確解碼—這些細胞的“譜係信息”在漫長的科學研究長河中,一直是科學中的重要和基本問題並沒有得到很好的解答。捕獲細胞譜係的多維信息,尤其是探究其在時間、空間維度的精確動態變化,是探索生命奧秘、解析發育程式、治愈疾病、延緩衰老的基礎;對細胞譜係的精準操控,是基於細胞治療、器官重建的未來再生醫學應用之不可或缺的前提。本實驗室圍繞細胞的時空動態譜係問題,主要開展以下研究:

    研究方向一:單細胞多組學與譜係示蹤技術解析細胞譜係的功能分群與異質性

    結合單細胞多組學測序、單細胞譜係示蹤、生物信息學、人工智能以及類器官等手段重點關注胚胎與組織中特定功能細胞的動態變化與細胞譜係決定的調控機製。

    研究方向二:原位空間多組學技術解析空間功能特異的細胞調控特征

    發展和利用高通量、高分辨率的空間多組學技術,研究組織功能實現的細胞基礎,揭示原位、動態、多維度的細胞命運決定與調控網絡。

    研究方向三:新型多能幹細胞用於體外器官重建與功能修複

    基於細胞譜係的新發現,實現譜係再造、損傷修複與器官的體外重建。

    主要學術成果

    聚焦細胞的時空動態譜係研究,以技術與數據驅動生物學新發現。開發了多種空間組學原創技術,繪製了小鼠著床後胚胎三個胚層建立過程高分辨率的時空動態分子圖譜,揭示了多能幹細胞的發育調控網絡,解析了小鼠大腦的時空動態譜係發育過程,發現了新型的組織幹細胞可用於體外器官重建與組織修複。發表研究論文及綜述七十餘篇,引用超過3000多次,通訊作者論文發表在NatureNature MethodsNature GeneticsAnnals of the Rheumatic DiseaseNature CommunicationsCell Reports等,研究成果獲選“2019年度中國生命科學十大進展“2019年度中國生物信息學十大進展“2019年度中國生物信息學十大應用”。

    承擔科研項目情況:

  • 中國科學院器官重建與製造”A類戰略性先導科技專項

    國家重點研發計劃幹細胞及轉化研究重點專項

    國家重點研發計劃“發育編程及其代謝調控”重點專項

    國家重點人才計劃高層次青年人才項目

    國家自然科學基金麵上項目

    廣東省自然科學基金傑出青年項目


    社會任職:

  • 國際幹細胞學會(ISSCR)會員


    獲獎及榮譽:

  • Sanofi-SIBS 2017 Distinguished Young Faculty

    ISSCR 2017 Poster Award and Travel Award

    國家級人才項目


    代表論著:

  • 2018-2024

    1.Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ,Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration.Ann Rheum DisIF27

    2.Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S*,Peng G*(2023) Three-dimensional molecular architecture of mouse organogenesis.Nat Commun,14:4599

    3.Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K,Peng G*(2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development.Nat Methods,20:1048–1057

    4.Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*,Peng G*, Jing N*(2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells.Cell Regen,12:15

    5.Meng X, Cui G,Peng G*(2023) Lung development and regeneration: newly defined cell types and progenitor status.Cell Regen,12:5

    6.Chen C, Liao Y,Peng G*(2022) Connecting past and present: single-cell lineage tracing.Protein Cell

    7.Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N*,Peng G*(2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo.Cell Rep,40:111285

    8.Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*,Peng G*, Ren X*, Jiang N*, Tian C*, Chen ZJ*(2022) Single-cell technologies: From research to application.Innovation(Camb),3:100342

    9.Li Z,Peng G(2021) Spatial transcriptomics: new dimension of understanding biological complexity.Biophysics Reports,7:1–17

    10.Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H,Peng G*, Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.Cell Prolif,54:e13000

    11.Lin J, Wu S, Shen Q, Liu J, Huang S,Peng G*, Qiao Y* (2021) Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo.Cell Prolif, e13096

    12.Peng, G.*, Cui, G., Ke, J. and Jing, N. (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development.Annu Rev Genomics Hum Genet2020; 21 163-181.

    13.Peng G#*, Suo S#, Cui G#, Yu F#, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ*, Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo.Nature, 572: 528–532

    14.Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N,Peng G*, Ji H*, Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction.Nat Genet, 51: 728–738

    15.Cui, G., Jing, N. andPeng, G.*(2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo’.J Mol Cell Biol11, 1024-1025.

    16.Peng G, Han JJ (2018) Regulatory network characterization in development: challenges and opportunities.F1000Res, 7:

    17.Cui G, Suo S, Wang R, Qian Y, Han JJ*,Peng G*, Tam PPL*, Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning.Dev Growth Differ, 60: 463–472

    18.Han X#, Luo S#,Peng G#, Lu JY, Cui G, Liu L, Yan P, Yin Y, Liu W, Wang R, Zhang J, Ai S, Chang Z, Na J, He A, Jing N, Shen X (2018) Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development.J Mol Cell Biol, 10: 175–178 

    2016-2018

    19.Peng G(2017) Looking Back: Single-Cell Analysis Empowering Stem Cell Studies (2017)Cell Stem Cell20: 758 (Commentary)

    20.Peng G, Tam PPL, Jing N (2017) Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies.National Science Review, 4: 533–542

    21.Peng G*, Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo.Sci China Life Sci, 60: 363–369

    22.Chen J#, Suo S#, Tam PP, Han JJ,Peng G*, Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq.Nat Protoc, 12: 566–580

    23.Peng G#, Suo S#, Chen J#, Chen W, Liu C, Yu F, Wang R, Chen S, Sun N, Cui G, Song L, Tam PP, Han JD*, Jing N* (2016) Spatial transcriptome for the molecular annotation of lineage fates and cell identity in mid-gastrula mouse embryo.Dev Cell, 36: 681–697 

    (*: corresponding author; #: first author)

    完整論文情況Google scholar:https://scholar.google.com/citations?user=s7XddBgAAAAJ

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